MersV1, Main, Exploration, bibRecord, 002932

Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination

Identifieur interne : 002932 ( Main/Exploration ); précédent : 002931; suivant : 002933

Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination

Auteurs : Wing-Pui Kong [États-Unis] ; LAN WU [États-Unis] ; Timothy C. Wallstrom [États-Unis] ; Will Fischer [États-Unis] ; Zhi-Yong Yang [États-Unis] ; Sung-Youl Ko [États-Unis] ; Norman L. Letvin [États-Unis] ; Barton F. Haynes [États-Unis] ; Beatrice H. Hahn [États-Unis] ; Bette Korber [États-Unis] ; Gary J. Nabel [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2009.

RBID : Pascal:09-0131147

Descripteurs français

Pascal (Inist)
- Virus HIV1, Immunité cellulaire, Vaccin génétique, Virologie, SIDA.

English descriptors

KwdEn :
- AIDS, Cellular immunity, Genetic vaccine, HIV-1 virus, Virology.

Abstract

An effective AIDS vaccine must control highly diverse circulating strains of human immunodeficiency virus type 1 (HIV-1). Among HIV-1 gene products, the envelope (Env) protein contains variable as well as conserved regions. In this report, an informatic approach to the design of T-cell vaccines directed to HIV-1 Env M group global sequences was tested. Synthetic Env antigens were designed to express mosaics that maximize the inclusion of common potential T-cell epitope (PTE) 9-mers and minimize the inclusion of rare epitopes likely to elicit strain-specific responses. DNA vaccines were evaluated using intracellular cytokine staining in inbred mice with a standardized panel of highly conserved 15-mer PTE peptides. One-, two-, and three-mosaic sets that increased theoretical epitope coverage were developed. The breadth and magnitude of T-cell immunity stimulated by these vaccines were compared to those for natural strain Envs; additional comparisons were performed on mutant Envs, including gp160 or gp145 with or without V regions and gp41 deletions. Among them, the two- or three-mosaic Env sets elicited the optimal CD4 and CD8 responses. These responses were most evident in CD8 T cells; the three-mosaic set elicited responses to an average of eight peptide pools, compared to two pools for a set of three natural Envs. Synthetic mosaic HIV-1 antigens can therefore induce T-cell responses with expanded breadth and may facilitate the development of effective T-cell-based HIV-1 vaccines.

Affiliations:

États-Unis

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000067
to stream PascalFrancis, to step Curation: 000027
to stream PascalFrancis, to step Checkpoint: 000067
to stream Main, to step Merge: 002958
to stream Main, to step Curation: 002932

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination</title>
<author><name sortKey="Kong, Wing Pui" sort="Kong, Wing Pui" uniqKey="Kong W" first="Wing-Pui" last="Kong">Wing-Pui Kong</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vaccine Research Center, NIAID, National Institutes of Health, Bldg. 40, Room 4502, MSC-3005, 40 Convent Drive</s1>
<s2>Bethesda, Maryland 20892-3005</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892-3005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lan Wu" sort="Lan Wu" uniqKey="Lan Wu" last="Lan Wu">LAN WU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vaccine Research Center, NIAID, National Institutes of Health, Bldg. 40, Room 4502, MSC-3005, 40 Convent Drive</s1>
<s2>Bethesda, Maryland 20892-3005</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892-3005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wallstrom, Timothy C" sort="Wallstrom, Timothy C" uniqKey="Wallstrom T" first="Timothy C." last="Wallstrom">Timothy C. Wallstrom</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Los Alamos National Laboratory, MS K710, T-10</s1>
<s2>Los Alamos, New Mexico 87545</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Los Alamos, New Mexico 87545</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fischer, Will" sort="Fischer, Will" uniqKey="Fischer W" first="Will" last="Fischer">Will Fischer</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Los Alamos National Laboratory, MS K710, T-10</s1>
<s2>Los Alamos, New Mexico 87545</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Los Alamos, New Mexico 87545</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Zhi Yong" sort="Yang, Zhi Yong" uniqKey="Yang Z" first="Zhi-Yong" last="Yang">Zhi-Yong Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vaccine Research Center, NIAID, National Institutes of Health, Bldg. 40, Room 4502, MSC-3005, 40 Convent Drive</s1>
<s2>Bethesda, Maryland 20892-3005</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892-3005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ko, Sung Youl" sort="Ko, Sung Youl" uniqKey="Ko S" first="Sung-Youl" last="Ko">Sung-Youl Ko</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vaccine Research Center, NIAID, National Institutes of Health, Bldg. 40, Room 4502, MSC-3005, 40 Convent Drive</s1>
<s2>Bethesda, Maryland 20892-3005</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892-3005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Letvin, Norman L" sort="Letvin, Norman L" uniqKey="Letvin N" first="Norman L." last="Letvin">Norman L. Letvin</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RE113, P.O. Box 15732</s1>
<s2>Boston, Massachusetts 021153</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, Massachusetts 021153</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Haynes, Barton F" sort="Haynes, Barton F" uniqKey="Haynes B" first="Barton F." last="Haynes">Barton F. Haynes</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Duke Human Vaccine Institute, Duke University Medical Center, MSRBII Building Room 4085, P.O. Box 103020, Research Drive</s1>
<s2>Durham, North Carolina 27710</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Durham, North Carolina 27710</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hahn, Beatrice H" sort="Hahn, Beatrice H" uniqKey="Hahn B" first="Beatrice H." last="Hahn">Beatrice H. Hahn</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine, University of Alabama at Birmingham, Kaul 816, 720 20th Street South</s1>
<s2>Birmingham, Alabama 35294</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Birmingham, Alabama 35294</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Korber, Bette" sort="Korber, Bette" uniqKey="Korber B" first="Bette" last="Korber">Bette Korber</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Los Alamos National Laboratory, MS K710, T-10</s1>
<s2>Los Alamos, New Mexico 87545</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Los Alamos, New Mexico 87545</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Santa Fe Institute, 1399 Hyde Park Road</s1>
<s2>Santa Fe, New Mexico 87501</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Santa Fe, New Mexico 87501</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nabel, Gary J" sort="Nabel, Gary J" uniqKey="Nabel G" first="Gary J." last="Nabel">Gary J. Nabel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vaccine Research Center, NIAID, National Institutes of Health, Bldg. 40, Room 4502, MSC-3005, 40 Convent Drive</s1>
<s2>Bethesda, Maryland 20892-3005</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892-3005</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0131147</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0131147 INIST</idno>
<idno type="RBID">Pascal:09-0131147</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000067</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000027</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000067</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000067</idno>
<idno type="wicri:doubleKey">0022-538X:2009:Kong W:expanded:breadth:of</idno>
<idno type="wicri:Area/Main/Merge">002958</idno>
<idno type="wicri:Area/Main/Curation">002932</idno>
<idno type="wicri:Area/Main/Exploration">002932</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination</title>
<author><name sortKey="Kong, Wing Pui" sort="Kong, Wing Pui" uniqKey="Kong W" first="Wing-Pui" last="Kong">Wing-Pui Kong</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vaccine Research Center, NIAID, National Institutes of Health, Bldg. 40, Room 4502, MSC-3005, 40 Convent Drive</s1>
<s2>Bethesda, Maryland 20892-3005</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892-3005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lan Wu" sort="Lan Wu" uniqKey="Lan Wu" last="Lan Wu">LAN WU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vaccine Research Center, NIAID, National Institutes of Health, Bldg. 40, Room 4502, MSC-3005, 40 Convent Drive</s1>
<s2>Bethesda, Maryland 20892-3005</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892-3005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wallstrom, Timothy C" sort="Wallstrom, Timothy C" uniqKey="Wallstrom T" first="Timothy C." last="Wallstrom">Timothy C. Wallstrom</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Los Alamos National Laboratory, MS K710, T-10</s1>
<s2>Los Alamos, New Mexico 87545</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Los Alamos, New Mexico 87545</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fischer, Will" sort="Fischer, Will" uniqKey="Fischer W" first="Will" last="Fischer">Will Fischer</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Los Alamos National Laboratory, MS K710, T-10</s1>
<s2>Los Alamos, New Mexico 87545</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Los Alamos, New Mexico 87545</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Zhi Yong" sort="Yang, Zhi Yong" uniqKey="Yang Z" first="Zhi-Yong" last="Yang">Zhi-Yong Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vaccine Research Center, NIAID, National Institutes of Health, Bldg. 40, Room 4502, MSC-3005, 40 Convent Drive</s1>
<s2>Bethesda, Maryland 20892-3005</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892-3005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ko, Sung Youl" sort="Ko, Sung Youl" uniqKey="Ko S" first="Sung-Youl" last="Ko">Sung-Youl Ko</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vaccine Research Center, NIAID, National Institutes of Health, Bldg. 40, Room 4502, MSC-3005, 40 Convent Drive</s1>
<s2>Bethesda, Maryland 20892-3005</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892-3005</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Letvin, Norman L" sort="Letvin, Norman L" uniqKey="Letvin N" first="Norman L." last="Letvin">Norman L. Letvin</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RE113, P.O. Box 15732</s1>
<s2>Boston, Massachusetts 021153</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, Massachusetts 021153</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Haynes, Barton F" sort="Haynes, Barton F" uniqKey="Haynes B" first="Barton F." last="Haynes">Barton F. Haynes</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Duke Human Vaccine Institute, Duke University Medical Center, MSRBII Building Room 4085, P.O. Box 103020, Research Drive</s1>
<s2>Durham, North Carolina 27710</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Durham, North Carolina 27710</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hahn, Beatrice H" sort="Hahn, Beatrice H" uniqKey="Hahn B" first="Beatrice H." last="Hahn">Beatrice H. Hahn</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine, University of Alabama at Birmingham, Kaul 816, 720 20th Street South</s1>
<s2>Birmingham, Alabama 35294</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Birmingham, Alabama 35294</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Korber, Bette" sort="Korber, Bette" uniqKey="Korber B" first="Bette" last="Korber">Bette Korber</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Los Alamos National Laboratory, MS K710, T-10</s1>
<s2>Los Alamos, New Mexico 87545</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Los Alamos, New Mexico 87545</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Santa Fe Institute, 1399 Hyde Park Road</s1>
<s2>Santa Fe, New Mexico 87501</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Santa Fe, New Mexico 87501</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nabel, Gary J" sort="Nabel, Gary J" uniqKey="Nabel G" first="Gary J." last="Nabel">Gary J. Nabel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Vaccine Research Center, NIAID, National Institutes of Health, Bldg. 40, Room 4502, MSC-3005, 40 Convent Drive</s1>
<s2>Bethesda, Maryland 20892-3005</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, Maryland 20892-3005</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Cellular immunity</term>
<term>Genetic vaccine</term>
<term>HIV-1 virus</term>
<term>Virology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus HIV1</term>
<term>Immunité cellulaire</term>
<term>Vaccin génétique</term>
<term>Virologie</term>
<term>SIDA</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">An effective AIDS vaccine must control highly diverse circulating strains of human immunodeficiency virus type 1 (HIV-1). Among HIV-1 gene products, the envelope (Env) protein contains variable as well as conserved regions. In this report, an informatic approach to the design of T-cell vaccines directed to HIV-1 Env M group global sequences was tested. Synthetic Env antigens were designed to express mosaics that maximize the inclusion of common potential T-cell epitope (PTE) 9-mers and minimize the inclusion of rare epitopes likely to elicit strain-specific responses. DNA vaccines were evaluated using intracellular cytokine staining in inbred mice with a standardized panel of highly conserved 15-mer PTE peptides. One-, two-, and three-mosaic sets that increased theoretical epitope coverage were developed. The breadth and magnitude of T-cell immunity stimulated by these vaccines were compared to those for natural strain Envs; additional comparisons were performed on mutant Envs, including gp160 or gp145 with or without V regions and gp41 deletions. Among them, the two- or three-mosaic Env sets elicited the optimal CD4 and CD8 responses. These responses were most evident in CD8 T cells; the three-mosaic set elicited responses to an average of eight peptide pools, compared to two pools for a set of three natural Envs. Synthetic mosaic HIV-1 antigens can therefore induce T-cell responses with expanded breadth and may facilitate the development of effective T-cell-based HIV-1 vaccines.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Kong, Wing Pui" sort="Kong, Wing Pui" uniqKey="Kong W" first="Wing-Pui" last="Kong">Wing-Pui Kong</name>
</noRegion>
<name sortKey="Fischer, Will" sort="Fischer, Will" uniqKey="Fischer W" first="Will" last="Fischer">Will Fischer</name>
<name sortKey="Hahn, Beatrice H" sort="Hahn, Beatrice H" uniqKey="Hahn B" first="Beatrice H." last="Hahn">Beatrice H. Hahn</name>
<name sortKey="Haynes, Barton F" sort="Haynes, Barton F" uniqKey="Haynes B" first="Barton F." last="Haynes">Barton F. Haynes</name>
<name sortKey="Ko, Sung Youl" sort="Ko, Sung Youl" uniqKey="Ko S" first="Sung-Youl" last="Ko">Sung-Youl Ko</name>
<name sortKey="Korber, Bette" sort="Korber, Bette" uniqKey="Korber B" first="Bette" last="Korber">Bette Korber</name>
<name sortKey="Korber, Bette" sort="Korber, Bette" uniqKey="Korber B" first="Bette" last="Korber">Bette Korber</name>
<name sortKey="Lan Wu" sort="Lan Wu" uniqKey="Lan Wu" last="Lan Wu">LAN WU</name>
<name sortKey="Letvin, Norman L" sort="Letvin, Norman L" uniqKey="Letvin N" first="Norman L." last="Letvin">Norman L. Letvin</name>
<name sortKey="Nabel, Gary J" sort="Nabel, Gary J" uniqKey="Nabel G" first="Gary J." last="Nabel">Gary J. Nabel</name>
<name sortKey="Wallstrom, Timothy C" sort="Wallstrom, Timothy C" uniqKey="Wallstrom T" first="Timothy C." last="Wallstrom">Timothy C. Wallstrom</name>
<name sortKey="Yang, Zhi Yong" sort="Yang, Zhi Yong" uniqKey="Yang Z" first="Zhi-Yong" last="Yang">Zhi-Yong Yang</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002932 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002932 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:09-0131147
   |texte=   Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination
}}

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination

Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri